Myocardial infarction

Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats

W. M. Wang, Liu, Z., Chen, G., Wang, W. M., Liu, Z., and Chen, G., Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats, vol. 15, p. -, 2016.

As the most common cardiac disease, myocardial infarction is followed by hypertrophy of cardiac myocytes and reconstruction of ventricular structure. The up-regulation of a series of factors including metalloproteinases, inflammatory factors, and growth factors after primary infarction lead to the hypertrophy, apoptosis, necrosis, and fibroblast proliferation in cardiac muscle tissues. Recent studies have reported on the potency of small interfering RNA (siRNA) in treating cardiac diseases.

Tiaogan Qingxin Granule treatment increases myocardial connexin 43 expression in a rat model of arrhythmia

J. H. Yao, Qu, C. H., Ma, L., Chang, X. Z., Yao, J. H., Qu, C. H., Ma, L., and Chang, X. Z., Tiaogan Qingxin Granule treatment increases myocardial connexin 43 expression in a rat model of arrhythmia, vol. 15, p. -, 2016.

Myocardial ischemia-induced arrhythmia, especially ventricular arrhythmia, is the main reason for sudden cardiac death. Therefore, ischemic ventricular arrhythmia-targeted treatments are urgently needed. The mechanism of Tiaogan Qingxin Granule in premature ventricular beat (PVB) treatment was explored in arrhythmic rats pretreated with Tiaogan Qingxin Granule. Sprague-Dawley rats (N = 40) were randomly divided into 4 groups: sham-operated, arrhythmia model, Wenxin Granule, and Tiaogan Qingxin Granule.

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