Mx gene

PCR-RFLP genotyping protocol for chicken Mx gene G/A polymorphism associated with the S631N mutation

L. Sironi, Ramelli, P., Williams, J. L., and Mariani, P., PCR-RFLP genotyping protocol for chicken Mx gene G/A polymorphism associated with the S631N mutation, vol. 9, pp. 1104-1108, 2010.

The Mx (myxovirus resistance) gene codes for a protein with antiviral activity. Non-synonymous G/A polymorphism at position 2032 of chicken Mx cDNA results in a change at amino acid 631 of the Mx protein. This mutation has been shown to affect the antiviral activity of the Mx molecule, although recent studies have not confirmed this effect in response to some influenza strains. Nevertheless, the G/A polymorphism could be important for the chicken’s response to other viruses.

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