Mutation

Mutations in WT1 in boys with sporadic isolated steroid-resistant nephrotic syndrome

Y. Yang, Zhao, F., Tu, X., Yu, Z., Yang, Y., Zhao, F., Tu, X., and Yu, Z., Mutations in WT1 in boys with sporadic isolated steroid-resistant nephrotic syndrome, vol. 15, p. -, 2016.

Mutations in the Wilms’ tumor gene, WT1, can lead to syndromic steroid-resistant nephrotic syndrome and isolated steroid-resistant nephrotic syndrome. WT1 mutations have been identified in the majority of children with Denys-Drash or Frasier syndrome. WT1 mutations have not previously been identified in boys with sporadic isolated steroid-resistant nephrotic syndrome, but, recently, four boys with isolated nephrotic syndrome were identified to have WT1 mutations.

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