Muscle-invasive bladder cancer

Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma

H. T. Niu, Qi, X. J., Liu, Y. Q., Cao, Y. W., Dong, Q., and Wang, X. S., Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma, vol. 12, pp. 4251-4263, 2013.

To bring about improvements in cancer biology research and elucidate mechanism-based therapeutic targets, we studied the proteome expression profile of purified normal urothelial cells (cancer cells) and normal stromal cells (cancerous stromal cells). Based on the expression profile, biomarker discovery and the mechanisms of multi-step carcinogenesis were explored. We found that 1412/1403 unique proteins commonly appeared in 4 sets of paired cancer/normal tissue, and 1753 proteins were differentially expressed.

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