Multiple testing

A new method for estimating the number of non-differentially expressed genes

J. Wu, Liu, C. Y., Chen, W. T., Ma, W. Y., Ding, Y., Wu, J., Liu, C. Y., Chen, W. T., Ma, W. Y., Ding, Y., Wu, J., Liu, C. Y., Chen, W. T., Ma, W. Y., and Ding, Y., A new method for estimating the number of non-differentially expressed genes, vol. 15, p. -, 2016.

Control of the false discovery rate is a statistical method that is widely used when identifying differentially expressed genes in high-throughput sequencing assays. It is often calculated using an adaptive linear step-up procedure in which the number of non-differentially expressed genes should be estimated accurately. In this paper, we discuss the estimation of this parameter and point out defects in the original estimation method. We also propose a new estimation method and provide the error estimation.

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