Mitochondrial tRNA mutations may be infrequent in hepatocellular carcinoma patients
“Mitochondrial tRNA mutations may be infrequent in hepatocellular carcinoma patients”, vol. 15, p. -, 2016.
, Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutations in this disease. As a result, several mt-tRNA mutations associated with HCC have been described. Some of these are neutral polymorphisms and may not cause mitochondrial dysfunction.