MRSA

Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization

K. Murugan, Kavitha, K., and Al-Sohaibani, S., Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization, vol. 14, pp. 2716-2725, 2015.

High-level methicillin-resistant Staphylococcus aureus (MRSA) isolates show rapid evolution of rifampicin resistance, forcing reliance upon expensive and often inferior antibiotics to manage these infections. Accordingly, this study was conducted to: 1) evaluate the level of multidrug resistance among hospital-associated MRSA isolates from Chennai, India; 2) determine their rifampicin resistance and molecular characterization; and 3) analyze the identified rpoB gene mutations for predominant high-level rifampicin resistance-associated nucleotide changes.

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