Module analysis

Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles

L. Dong, Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., and Chen, C. Y., Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles, vol. 15, p. -, 2016.

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were identified using microRNA (miRNA) and mRNA expression profiles. Differentially expressed (DE) miRNA targets were predicted by combining five algorithms.

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