MMP-9

Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women

C. Sun, Zhang, Q., Hu, B., Zhang, K., Sun, C., Zhang, Q., Hu, B., and Zhang, K., Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women, vol. 15, p. -, 2016.

We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using polymerase chain reaction-restriction fragment length polymorphism assay.

MMP-9 genetic polymorphism may confer susceptibility to COPD

S. Jiang, Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., and Tan, M. Q., MMP-9 genetic polymorphism may confer susceptibility to COPD, vol. 15, p. -, 2016.

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% confidence intervals was applied to assess the correlation between genetic polymorphisms of MMPs and susceptibility to COPD. Twelve high-quality studies were selected for inclusion in this meta-analysis.

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