MMP-2

Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression

Z. Peng, Zhang, Y., Peng, Z., Zhang, Y., Peng, Z., and Zhang, Y., “Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression”, vol. 15, p. -, 2016.

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 activity. The protein expression levels of matrix metalloproteinase-2 (MMP-2) were detected by western blotting.

High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis

G. Q. Zeng, Chen, A. B., Li, W., Song, J. H., and Gao, C. Y., “High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis”, vol. 14, pp. 14811-14822, 2015.

Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The STATA 12.0 software was used for the statistical analyses. A total of 1408 studies were initially searched, and 10 studies with 458 OA patients and 295 healthy controls were included in this meta-analysis.

Expression characteristics of MMP-2 and MMP-9 in guinea pig ovaries during the estrous cycle

J. R. Li and Shen, T., “Expression characteristics of MMP-2 and MMP-9 in guinea pig ovaries during the estrous cycle”, vol. 14, pp. 17329-17340, 2015.

We investigated the expression characteristics of matrix metalloproteinases (MMP)-2 and MMP-9 in the ovaries of normal adult guinea pigs during the estrous cycle. The estrous cycle was classified according to the appearance of the vaginal orifice and by vaginal exfoliated cell smears. Guinea pigs that had experienced at least two normal estrous cycles were selected. Ovaries were collected from guinea pigs at proestrus or metestrus (N = 6).

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