Mitotic index

Effects of the plant steroidal hormone, 24-epibrassinolide, on the mitotic index and growth of onion (Allium cepa) root tips

W. M. Howell, Keller, III, G. E., Kirkpatrick, J. D., Jenkins, R. L., Hunsinger, R. N., and McLaughlin, E. W., Effects of the plant steroidal hormone, 24-epibrassinolide, on the mitotic index and growth of onion (Allium cepa) root tips, vol. 6, pp. 50-58, 2007.

The purpose of the present study was to determine the effects of the steroidal plant hormone, 24-epibrassinolide (BL), on the mitotic index and growth of onion (Allium cepa) root tips. The classical Allium test was used to gather and quantify data on the rate of root growth, the stages of mitosis, and the number of mitoses in control and BL-treated groups of onions. Low doses of BL (0.005 ppm) nearly doubled the mean root length and the number of mitoses over that of controls.

Evaluation of the mutagenic activity of hydroxyurea on the G1-S-G2 phases of the cell cycle: an in vitro study

P. Danielle L. de Lima, Cardoso, P. Cerqueira, Khayat, A. Salim, Bahia, Mde Oliveir, and Burbano, R. Rodríguez, Evaluation of the mutagenic activity of hydroxyurea on the G1-S-G2 phases of the cell cycle: an in vitro study, vol. 2, pp. 328-333, 2003.

Hydroxyurea is considered an antineoplastic drug, which also plays an important role in the treatment of sickle cell anemia patients. We evaluated and compared the clastogenic and cytotoxic effects of hydroxyurea, using chromosomal aberrations and mitotic index, respectively, as endpoints. In vitro short-term cultures of lymphocytes were exposed to several concentrations of this drug, at various cell cycle phases. There was a significant increase in the cytotoxicity of hydroxyurea at G1 and G1/S as well in the G2 phase of the cell cycle.

The anticancer homeopathic composite “Canova Method” is not genotoxic for human lymphocytes in vitro

I. C. Seligmann, Lima, P. D. L., Cardoso, P. C. S., Khayat, A. S., Bahia, M. O., Buchi, Dde Freitas, Cabral, I. R., and Burbano, R. R., The anticancer homeopathic composite “Canova Method” is not genotoxic for human lymphocytes in vitro, vol. 2, pp. 223-228, 2003.

The Canova Methodâ (CM) is a homeopathic medicine indicated for the treatment of patients with cancer and for pathologies that involve a depressed immune system, such as AIDS. This product is composed of homeopathic dilutions of Aconitum napellus, Arsenicum album (arsenic trioxide), Bryonia alba, Lachesis muta venom and Thuya occidentalis. It stimulates the immune system by activating macrophages.

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