Mitochondrion

MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice

L. Song, Zhang, Z. R., Zhang, J. L., Zhu, X. B., He, L., Shi, Z., Gao, L., Li, Y., Hu, B., and Feng, F. M., MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice, vol. 14, pp. 13258-13265, 2015.

Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and indices of oxidative stress during liver injury in mice after administration of isoniazid, a first-line anti-tuberculosis drug.

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