Mitochondrial tRNA mutations

Mitochondrial transfer RNA mutations and hypertension

S. L. Yin, Lan, C., Pei, H., and Zhu, Z. Q., Mitochondrial transfer RNA mutations and hypertension, vol. 14, pp. 17692-17698, 2015.

Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is known for its high frequency of polymorphisms and mutations, and the number of reports regarding mt-tRNA mutations and hypertension is increasing significantly.

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