Missense mutation

R337H mutation of the TP53 gene as a clinical marker in cancer patients: a systematic review of literature

L. M. Borges and Ayres, F. M., R337H mutation of the TP53 gene as a clinical marker in cancer patients: a systematic review of literature, vol. 14, pp. 17034-17043, 2015.

The germline R337H mutation of the TP53 gene has been associated with the development of many tumor types. This systematic review of literature investigated the association between the R337H mutation and the patients’ family history and its predictive and prognostic value in cancer. Data were collected from articles archived in the PubMed, LILACS, MEDLINE, IBECS, and SciELO databases.

One missense mutation in exon 2 of the PAX5 gene in Iran

S. Yazdanparast, Khatami, S. R., Galehdari, H., and Jaseb, K., One missense mutation in exon 2 of the PAX5 gene in Iran, vol. 14, pp. 17768-17775, 2015.

The PAX5 gene, which encodes the B-cell specific activator protein, is one of the most important factors in determination of B-cell development. This gene is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). For example, point mutations, deletions, as well as other gene rearrangements may lead to several forms of B-cell malignancy. In this study, we obtained 50 blood samples from patients diagnosed with ALL, and screened for PAX5 mutations using sequencing in exons 1, 2 and 3.

Establishment and rapid detection of a heterozygous missense mutation in the CACNA1F gene by ARMS technique with double-base mismatched primers

W. C. Yang, Zhu, L., Zhou, B. X., Tania, S., Zhou, Q., Khan, M. A., Fu, X. L., Cheng, J. L., Lv, H. B., and Fu, J. J., Establishment and rapid detection of a heterozygous missense mutation in the CACNA1F gene by ARMS technique with double-base mismatched primers, vol. 14, pp. 11480-11487, 2015.

Retinitis pigmentosa (RP) is a retinal degenerative disorder that often causes complete blindness. Mutations of more than 50 genes have been identified as associated with RP, including the CACNA1F gene. In a recent study, by employing next-generation sequencing, we identified a novel mutation in the CACNA1F gene.

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