MiR-874

Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma

L. Q. Zhang, Sun, S. L., Li, W. Y., Feng, Z., Xu, X. Y., Zhuang, Q. S., and Fang, J., Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma, vol. 14, pp. 18315-18324, 2015.

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) in human osteosarcoma cell lines and tissues.

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