MiR-29c

Low miR-29c expression is a prognostic marker in hepatocellular carcinoma

C. W. Dong, Wang, Y. X., Du, F. T., Ding, W., Hu, S. Y., Dong, C. W., Wang, Y. X., Du, F. T., Ding, W., and Hu, S. Y., Low miR-29c expression is a prognostic marker in hepatocellular carcinoma, vol. 15, p. -, 2016.

A previous study has revealed that miR-29c functions as a tumor suppressor in hepatocellular carcinoma (HCC), but the clinical significance and prognostic value of miR-29c in HCC have not been investigated. Paired human HCC tissues and adjacent noncancerous tissues were obtained from 91 patients, between 2008 to 2014. Quantitative real-time PCR (qRT-PCR) was used to analyze miR-29c expression. Kaplan-Meier survival plots and log-rank tests were used to assess differences in the overall survival of different subgroups of HCC patients.

Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models

J. Y. Wang, Li, Z. H., Ye, M., Feng, Q., Chen, Z. M., Ye, X. S., Wu, Z. G., Wang, B., Liu, L., Yao, J., Wang, J. Y., Li, Z. H., Ye, M., Feng, Q., Chen, Z. M., Ye, X. S., Wu, Z. G., Wang, B., Liu, L., and Yao, J., Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models, vol. 15, p. -, 2016.

Biliary atresia (BA) is a destructive bile duct disease occurring in newborn children within a few weeks after birth. In this study, the effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition (EMT) in experimental BA was explored by constructing BA mouse models via Rhesus rotavirus vaccine infection. miR-29c and miR-129-5p expression was analyzed by real-time quantitative polymerase chain reaction. EMT was established by induction with transforming growth factor (TGF)-β1.

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