miR-26a

Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells

M. Li, Chen, X. M., Wang, D. M., Gan, L., Qiao, Y., Li, M., Chen, X. M., Wang, D. M., Gan, L., and Qiao, Y., Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells, vol. 15, p. -, 2016.

The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR-26a mimic, antagomir-26a, or control mimic. The Beclin 1 mRNA and protein levels were detected by quantitative polymerase chain reaction and western blot, respectively. The activity of Beclin 1 3ꞌ-UTR reporter gene was detected with the luciferase assay. After transfection with miR-26a mimic, Beclin 1 mRNA and protein levels as well as the activity of the 3'-UTR reporter gene decreased.

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