miR-146a

miR-146a and miR-196a2 polymorphisms in ovarian cancer risk

X. C. Sun, Zhang, A. C., Tong, L. L., Wang, K., Wang, X., Sun, Z. Q., Zhang, H. Y., Sun, X. C., Zhang, A. C., Tong, L. L., Wang, K., Wang, X., Sun, Z. Q., and Zhang, H. Y., miR-146a and miR-196a2 polymorphisms in ovarian cancer risk, vol. 15, p. -, 2016.

We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain reaction coupled with restriction fragment length polymorphism analysis.

Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma

L. H. Zhang, Hao, B. B., Zhang, C. Y., Dai, X. Z., Zhang, F., Zhang, L. H., Hao, B. B., Zhang, C. Y., Dai, X. Z., and Zhang, F., Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma, vol. 15, p. -, 2016.

Hepatocellular carcinoma is one of the most common malignant tumors worldwide; it is estimated that there were 782,000 new cases in 2012. MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors. We investigated the role of miR-146a, miR-196a2, and miR-499 polymorphisms in the risk of hepatocellular carcinoma in a Chinese population. Hepatocellular carcinoma patients (175) and healthy controls (302) were recruited between April 2013 and March 2015.

Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer

J. Y. Gu, Tu, L., Gu, J. Y., and Tu, L., Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer, vol. 15, p. -, 2016.

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism.

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

M. Chen, Zhou, Z. Y., Chen, J. G., Tong, N., Chen, S. Q., Yang, Y., Zhang, X. W., Jiang, H., Liu, N., Liu, J., Sha, G. Z., Zhu, W. D., Hua, L. X., Wang, Z. J., and Xu, B., Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population, vol. 13, pp. 10615-10621, 2014.

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model.

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