MicroRNAs

Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis

M. Zhang, Zhao, L. J., Liang, W. Q., and Mao, Z. P., Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis, vol. 14, pp. 16562-16576, 2015.

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August 4, 2014 was conducted in databases and other sources. Statistical analysis was conducted using STATA 12.0.

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

G. J. Zhou, Xiao, M., Zhao, L. N., Tang, J. G., and Zhang, L., MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis, vol. 14, pp. 7279-7289, 2015.

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

Identification of conserved microRNAs and their target genes in Nile tilapia (Oreochromis niloticus) by bioinformatic analysis

X. H. Li, Wu, J. S., Tang, L. H., and Hu, D., Identification of conserved microRNAs and their target genes in Nile tilapia (Oreochromis niloticus) by bioinformatic analysis, vol. 14, pp. 2785-2792, 2015.

MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in posttranscriptional regulation of target genes. miRNAs are involved in multiple biological processes by degrading targeted mRNAs or repressing mRNA translation in various organisms. Their conserved nature in various organisms makes them a good source of new miRNA discovery using comparative genomic approaches.

Identification of highly expressed host microRNAs that respond to white spot syndrome virus infection in the Pacific white shrimp Litopenaeus vannamei (Penaeidae)

D. G. Zeng, Chen, X. L., Xie, D. X., Zhao, Y. Z., Yang, Q., Wang, H., Li, Y. M., and Chen, X. H., Identification of highly expressed host microRNAs that respond to white spot syndrome virus infection in the Pacific white shrimp Litopenaeus vannamei (Penaeidae), vol. 14, pp. 4818-4828, 2015.

MicroRNAs (miRNAs) are known to play an important role in regulating both adaptive and innate immunity. Pacific white shrimp (Litopenaeus vannamei) is the most widely farmed crustacean species in the world. However, little is known about the role miRNAs play in shrimp immunity. To understand the impact of viral infection on miRNA expression in shrimp, we used high-throughput sequencing technology to sequence two small RNA libraries prepared from L. vannamei under normal and white spot syndrome virus (WSSV) challenged conditions.

Computational identification of miRNAs and their targets in Phaseolus vulgaris

J. Han, Xie, H., Kong, M. L., Sun, Q. P., Li, R. Z., and Pan, J. B., Computational identification of miRNAs and their targets in Phaseolus vulgaris, vol. 13, pp. 310-322, 2014.

MicroRNAs (miRNAs) are a class of non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level. Although thousands of miRNAs have been identified in plants, limited information is available about miRNAs in Phaseolus vulgaris, despite it being an important food legume worldwide. The high conservation of plant miRNAs enables the identification of new miRNAs in P. vulgaris by homology analysis.

Prediction of potential novel microRNAs in soybean when in symbiosis

G. A. Barros-Carvalho, Paschoal, A. R., Marcelino-Guimarães, F. C., and Hungria, M., Prediction of potential novel microRNAs in soybean when in symbiosis, vol. 13, pp. 8519-8529, 2014.

MicroRNAs (miRNAs) are small molecules, noncoding proteins that are involved in many biological processes, especially in plants; among these processes is nodulation in the legume. Biological nitrogen fixation is a key process, with critical importance to the soybean crop. This study aimed to identify the potential of novel miRNAs to act during the root nodulation process.

MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer

X. W. Wang, Wu, Y., Wang, D., and Qin, Z. F., MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer, vol. 13, pp. 8695-8703, 2014.

To identify potential targets for the early treatment and prevention of gastric cancer, microRNA (miRNA) expression profiles of precancerous lesions of gastric cancer were investigated. The miRNA microarray dataset GSE24839 was downloaded from Gene Expression Omnibus (GEO) and included 10 Helicobacter pylori-related gastritis samples and 10 gastric intestinal metaplasia samples. Differentially expressed miRNAs (DEMs) were screened using the Student t-test; P H.

Benchmark comparison of ab initio microRNA identification methods and software

L. L. Hu, Huang, Y., Wang, Q. C., Zou, Q., and Jiang, Y., Benchmark comparison of ab initio microRNA identification methods and software, vol. 11, pp. 4525-4538, 2012.

MicroRNAs (miRNAs) are short, non-coding RNA molecules that play an important role in the world of genes, especially in regulating the gene expression of target messenger RNAs through cleavage or translational repression of messenger RNA. Ab initio methods have become popular in computational miRNA detection. Most software tools are designed to distinguish miRNA precursors from pseudo-hairpins, but a few can mine miRNA from genome or expressed sequence tag sequences. We prepared novel testing datasets to measure and compare the performance of various software tools.

Identification of miRNAs and their targets in wheat (Triticum aestivum L.) by EST analysis

J. Han, Kong, M. L., Xie, H., Sun, Q. P., Nan, Z. J., Zhang, Q. Z., and Pan, J. B., Identification of miRNAs and their targets in wheat (Triticum aestivum L.) by EST analysis, vol. 12, pp. 3793-3805, 2013.

MicroRNAs (miRNAs) are a newly discovered class of noncoding small RNAs that regulate gene expression by directing target mRNA cleavage or translational inhibition. A large number of miRNAs have been identified in plants. Increasing evidence has shown that miRNAs play multiple roles in plant biological processes. So far, identification of miRNAs has been limited to a few model plant species, whose genomes have been sequenced. Wheat (Triticum aestivum L.) is one of the most important cereal crops worldwide. To date, only a few conserved miRNAs have been predicted in wheat.

Identification and characterization of conserved microRNAs and their target genes in wheat (Triticum aestivum)

Z. J. Yin and Shen, F. F., Identification and characterization of conserved microRNAs and their target genes in wheat (Triticum aestivum), vol. 9, pp. 1186-1196, 2010.

MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression by translational repression or transcript degradation. A large number of miRNAs have been identified from model plant species; however, the character of conserved miRNAs is poorly understood. We studied 42 miRNA families that are conserved within the plant kingdom, using the miRBase database. Some conserved miRNA families were found to be preferentially expressed in dicots relative to monocots, especially miR403, miR472 and miR479.

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