Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma
“Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma”, vol. 14, pp. 6943-6952, 2015.,
MicroRNA-143 serves as a tumor suppressor in many human malignancies. However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. In this study, we investigated the effects of miR-143 in OSCC tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected miR-143 expression in 109 pairs of human OSCC and adjacent noncancerous tissues. The associations between miR-143 expression and clinicopathological factors and prognosis of OSCC patients were also statistically analyzed.