MicroRNA

Expressional analysis of immune-related miRNAs in breast milk

R. S. Na, E, G. X., Sun, W., Sun, X. W., Qiu, X. Y., Chen, L. P., and Huang, Y. F., Expressional analysis of immune-related miRNAs in breast milk, vol. 14, pp. 11371-11376, 2015.

Immune-related miRNAs in breast milk are extracellular miRNAs that are related to immune organ development and regulation of the immune function in infants and young animals. The goal of this study was to compare the expression levels of five immune-related miRNAs in breast milk in black goats, humans, and dairy cattle. The miRNAs from milk were extracted and the expression levels were assessed using quantitive RT-PCR methods.

Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer

F. Q. Li, Xu, B., Wu, Y. J., Yang, Z. L., and Qian, J. J., Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer, vol. 14, pp. 739-747, 2015.

Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression between the signet-ring cell carcinoma and tubular adenocarcinoma subtypes of gastric cancer.

Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma

D. Li, Peng, J. J., Tan, Y., Chen, T., Wei, D., Du, M., and Zhang, T., Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma, vol. 14, pp. 1926-1931, 2015.

We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism.

Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299

G. M. Chen, Ding, R. F., Tan, Y. D., Pan, X. B., Jiang, G. M., He, J. F., Lin, S. H., Liu, C., and Jia, Y., Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299, vol. 14, pp. 4005-4014, 2015.

Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies examining the function of CKIP1 in cancer cells have been performed. The present study aimed to investigate the role of CKIP1 in lung cancer.

Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis

G. Q. Zhou, Meng, H., Wang, J. R., Sun, F. X., Wang, X. J., Wang, R. B., and Wang, X. B., Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis, vol. 14, pp. 4767-4777, 2015.

Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed of the MEDLINE EMBASE, CNKI, and CBM databases to identify relevant articles published up to February 18, 2014.

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population

P. Qi, Wang, L., Zhou, B., Yao, W. J., Xu, S., Zhou, Y., and Xie, Z. B., Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population, vol. 14, pp. 6289-6296, 2015.

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A>G; miR-27a rs895819 A>G; miR-196a2 rs11614913 T>C; miR-146a rs2910164 G/C) were detected using Taqman assays.

Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 in pig adipose tissue

R. L. Qi, Chen, Y., Huang, J. X., and Yang, F. Y., Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 in pig adipose tissue, vol. 14, pp. 6985-6992, 2015.

In this study, we evaluated the effect and possible mech­anism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were col­lected, and real-time polymerase chain reaction (PCR) was used to de­termine the expression of adipocyte differentiation marker genes and associated microRNAs (miRNAs).

MicroRNAs function primarily in the pathogenesis of human anencephaly via the mitogen-activated protein kinase signaling pathway

W. D. Zhang, Yu, X., Fu, X., Huang, S., Jin, S. J., Ning, Q., and Luo, X. P., MicroRNAs function primarily in the pathogenesis of human anencephaly via the mitogen-activated protein kinase signaling pathway, vol. 13, pp. 1015-1029, 2014.

Anencephaly is one of the most serious forms of neural tube defects (NTDs), a group of congenital central nervous system (CNS) malformations. MicroRNAs (miRNAs) are involved in diverse biological processes via the post-transcriptional regulation of target mRNAs. Although miRNAs play important roles in the development of mammalian CNS, their function in human NTDs remains unknown.

Prediction and extraction of microRNA2target interactions associated with leukemia

L. Gong, Yan, Q., Yang, R., and Sun, X., Prediction and extraction of microRNA2target interactions associated with leukemia, vol. 13, pp. 2120-2129, 2014.

MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of diseases. To understand microRNAs’ function, it is vital to identify microRNA2target interactions. This work explores the prediction and extraction of leukemia-associated microRNA2target interactions, based on text mining. We extracted 371 interactions of microRNA2targets that, from prior knowledge, could be related to leukemia.

New support vector machine-based method for microRNA target prediction

L. Li, Gao, Q., Mao, X., and Cao, Y., New support vector machine-based method for microRNA target prediction, vol. 13, pp. 4165-4176, 2014.

MicroRNA (miRNA) plays important roles in cell differentiation, proliferation, growth, mobility, and apoptosis. An accurate list of precise target genes is necessary in order to fully understand the importance of miRNAs in animal development and disease. Several computational methods have been proposed for miRNA target-gene identification. However, these methods still have limitations with respect to their sensitivity and accuracy. Thus, we developed a new miRNA target-prediction method based on the support vector machine (SVM) model.

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