Microbubble

Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent

S. L. Yang, Mu, Y. M., Tang, K. Q., Jiang, X. K., Bai, W. K., Shen, E., and Hu, B., Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent, vol. 12, pp. 1318-1326, 2013.

Ultrasound-targeted microbubble destruction (UTMD) has been recently developed for destroying bubbles carrying drugs or genes, thereby permitting local release of these target molecules. We in­vestigated whether SonoVue®, a new contrast agent that contains phos­pholipid-stabilized microbubbles filled with sulfur hexafluoride vapor, is effective at delivering a recombinant adeno-associated viral (rAAV) vector to the rat heart by UTMD.

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