Mice

A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice

X. Wang, Song, Z. G., Huang, D. X., Gao, H., Wang, Q., Wang, Z. P., Wang, X., Song, Z. G., Huang, D. X., Gao, H., Wang, Q., and Wang, Z. P., A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice, vol. 15, p. -, 2016.

GABAA receptors are chloride channels in the brain that are activated by binding with g-aminobutyric acid (GABA). The cDNA sequences of GABAA receptor subunits from two strains of mice with different sensitivities to isoflurane were compared to identify nucleotide mutations. Included 80 mice from two strains with different sensitivities to isoflurane on C57BL/6 background. Forty mice were from an isoflurane-sensitive strain (S group) and 40 mice were from a resistant strain (R group).

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