Mice

Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses

W. B. Cantero, Takahachi, N. A., Mauro, M. O., Pesarini, J. R., Rabacow, A. P. M., Antoniolli, A. C. M. B., and Oliveira, R. J., Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses, vol. 14, pp. 2422-2435, 2015.

The present study investigated the effects of restricting protein and calories and supplementation of inulin, a fiber comprising a linear type of polydisperse carbohydrates composed primarily of fructil-fructose bonds (β-(2→1), on the deficiency statuses of animals in which genomic lesion development and colorectal carcinogenesis had been induced. This experiment involved adult male Swiss mice (N = 11/group). The experimental groups were as follows: Negative Control (vehicle), Positive Control, 1,2-dimethylhydrazine (DMH), Inulin, and Associate.

Assessment of the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus)

L. A. Assunção, Lemes, S. R., Araújo, L. A., Costa, C. R., Magalhães, L. G., Moura, K. K., and Melo-Reis, P. R., Assessment of the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus), vol. 14, pp. 6323-6329, 2015.

The present study aimed to assess the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus), which is commonly used as an anti-rheumatic, analgesic, antimicrobial, anticercariae, and anti-inflammatory. We used the mouse bone marrow micronucleus test as an experimental model. The experimental groups, which consisted of 5 animals, was administered sucupira oil (100 mg/kg body weight) intraperitoneally and evaluated 24 h after the treatment.

Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice

S. Wei, Gong, Z., An, L., Zhang, T., Dai, H., and Chen, S., Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice, vol. 14, pp. 7184-7195, 2015.

This study investigated the effects of pregnant mare se­rum gonadotropin (PMSG) and cloprostenol (CLO) on estrus induc­tion and synchronization, uterine development, and follicle-stimulating hormone receptor (FSHR) expression in mice. A total of 105 Kunming pre-puberty mice were divided into seven subgroups. Three PMSG sub­groups were injected intraperitoneally with 10, 20, and 40 IU PMSG twice (on days 0 and 4), and three CLO subgroups were injected intra­peritoneally with 10, 15, and 20 μg cloprostenol acetate twice (on days 0 and 4).

Effects of phenylalanine on reproductive performance and teratogenesis in mice

R. J. Oliveira, Pesarini, J. R., Mauro, M. O., Fronza, L. S., Victorelli, S. G., Cantero, W. B., Sena, M. C., and Antoniolli, A. C. M. B., Effects of phenylalanine on reproductive performance and teratogenesis in mice, vol. 13, pp. 5606-5616, 2014.

We evaluated the effects of phenylalanine on reproductive performance and teratogenesis in mice, as well as we assessed its protective effect in mice treated with an acute dose of cyclophosphamide. Animals were divided into 6 experimental groups (females N = 15/group, males N = 5/group): G1, the negative control group, phosphate-buffered saline; G2, the positive control group, 35 mg cyclophosphamide/kg body weight (b.w.); G3 and G4 received phenylalanine at doses of 150 and 300 mg/ kg b.w., respectively; G5 and G6 received phenylalanine at doses of 150 and 300 mg/kg b.w.

Damaging effects of water-borne cadmium chloride on DNA of lung cells of immature mice

X. F. Yang, Ge, Y. M., Zhang, H. T., Ning, H. M., Jiang, J. Q., Qi, Y. H., and Wang, Z. L., Damaging effects of water-borne cadmium chloride on DNA of lung cells of immature mice, vol. 11, pp. 4323-4329, 2012.

We investigated the effects of cadmium on lung cell DNA in immature mice. The mice were randomly divided into four groups: control group, low-dose group (1/100 LD50), middle-dose group (1/50 LD50), and high-dose group (1/25 LD50); they were supplied with cadmium chloride or control water for 40 days. Lung cells collected from sacrificed mice were used to evaluate the extent of DNA damage by comet assay.

Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine

D. F. Jiang, Zhang, X. G., Yang, H. L., and Sun, C., Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine, vol. 12, pp. 1501-1510, 2013.

Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously injected with evodiamine (37°C, 20 mg/kg), and the core body temperature change and expression levels of lipid metabolism-related genes were evaluated at baseline, 0.5, 1, and 2 h.

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

D. C. S. Lima, Silva, C. R., Sampaio, B. L., de Paula, J. R., and Chen-Chen, L., Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice, vol. 12, pp. 3887-3896, 2013.

Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleus test.

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