Methionine synthase reductase

Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males

X. Y. Li, Ye, J. Z., Ding, X. P., Zhang, X. H., Ma, T. J., Zhong, R., and Ren, H. Y., “Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males”, vol. 14, pp. 3491-3500, 2015.

We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population. This case-control study included 162 infertile Chinese patients with azoospermia (N = 100) or oligoasthenozoospermia (N = 62) and 120 fertile men as controls.

A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population

W. Zeng, Liu, L., Tong, Y., Liu, H. M., Dai, L., and Mao, M., “A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population”, vol. 10, pp. 2597-2605, 2011.

Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C524T) of the MTRR gene are associated with CHDs. A total of 599 children with CHDs and 672 healthy children were included; the polymorphisms were detected by PCR and RFLP analysis.

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