Metastasis

NDC80 promotes proliferation and metastasis of colon cancer cells

X. K. Xing, Wu, H. Y., Chen, H. L., Feng, H. G., Xing, X. K., Wu, H. Y., Chen, H. L., and Feng, H. G., NDC80 promotes proliferation and metastasis of colon cancer cells, vol. 15, p. -, 2016.

Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods.

miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2

P. Wang, Lv, H. Y., Zhou, D. M., Zhang, E. N., Wang, P., Lv, H. Y., Zhou, D. M., and Zhang, E. N., miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2, vol. 15, p. -, 2016.

Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, miR-204 expression was found to be down-regulated, and that of Janus kinase 2 (JAK2) was found to be up-regulated in four NSCLC cell lines (A549, H1299, H1650, and H358) compared to the normal lung cell line.

Metastasis-associated gene 1 expression in human medulloblastoma and its association with invasion and metastasis in medulloblastoma Daoy cell lines

Y. S. Chen, Li, S. P., Xiao, H., Xie, Z. Y., Tan, M. X., Liu, B., Zhang, W. M., Chen, Y. S., Li, S. P., Xiao, H., Xie, Z. Y., Tan, M. X., Liu, B., and Zhang, W. M., Metastasis-associated gene 1 expression in human medulloblastoma and its association with invasion and metastasis in medulloblastoma Daoy cell lines, vol. 15, p. -, 2016.

This study aims to investigate the expression of metastasis-associated gene 1 (MTA1) in human medulloblastoma, and its significance in the invasion and metastasis in a medulloblastoma cell line. Positive expression rate of MTA1 protein in medulloblastoma and adjacent normal tissues collected from 29 medulloblastoma patients was detected by immunohistochemistry assay in vivo. In in vitro experiments, Daoy cells were transfected with MTA1-targeted small interfering RNA (siRNA, MTA1-siRNA group), niRNA (MTA1-niRNA group), and plasmid vectors (control group).

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