Metastasis

Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer

T. Y. Sun, Yan, W., Yang, C. M., Zhang, L. F., Tang, H. L., Chen, Y., Hu, H. X., and Wei, X., Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer, vol. 14, pp. 16222-16232, 2015.

We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitization with lysis of autologous liver cancer cells. One hundred and sixty patients with hepatocellular carcinoma were randomly divided into two groups of 80. One group was treated postoperatively with six cycles of the DC tumor vaccine.

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