Metals

In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays

G. H. Westphalen, Menezes, L. M., Prá, D., Garcia, G. G., Schmitt, V. M., Henriques, J. A. P., and Medina-Silva, R., In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays, vol. 7, pp. 1259-1266, 2008.

Orthodontic appliances are usually made of stainless steel, which contains metals such as nickel, chromium and iron that have been associated with DNA damage. The aim of the present study was to determine the genetic toxicity associated with orthodontic fixed appliances in twenty healthy patients (16 ± 2.5 years) undergoing orthodontic treatment (fixed appliances - basic composition: stainless steel alloy), using the micronucleus (MN) and comet (CA) assays in buccal cells.

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