Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy
“Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy”, vol. 14, pp. 11043-11051, 2015.,
Oxythiamine (OT) has been proven to be a potential anticancer drug. With the help of NMR-based metabonomics, we studied the metabolic changes within tumor-bearing mice with different levels of OT administration using a C57BL/6 mouse Lewis lung carcinoma tumor transplantation model. We administered different concentrations of OT (75, 150, 300, and 600 mg∙kg-1∙day-1) to the mice orally for 2 weeks, recorded animal weights and tumor volumes, sacrificed the animals, and collected blood and tumor mass samples for nuclear magnetic resonance determination.