Metabolism

Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues

D. F. Jiang, Li, W. T., Yang, H. L., Zhang, Z. Z., Chen, D., and Sun, C., “Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues”, vol. 13, pp. 1038-1046, 2014.

Evodiamine, the major alkaloid component isolated from the fruit of dried, unripened Evodia rutaecarpa Bentham, affects the plasma levels of cholecystokinin and various biological events such as gastric emptying and gastrointestinal transit; these effects of evodiamine were previously investigated in male rats. In this study, we aimed to investigate the effects of evodiamine on average daily weight gain, rectal temperature, and expressions of genes involved in lipid metabolism in liver and adipose tissues.

In silico reconstruction of the amino acid metabolic pathways of Trypanosoma cruzi

A. C. R. Guimarães, Otto, T. D., Alves-Ferreira, M., Miranda, A. B., and Degrave, W. M., “In silico reconstruction of the amino acid metabolic pathways of Trypanosoma cruzi”, vol. 7, pp. 872-882, 2008.

Trypanosoma cruzi is the epidemiological agent of Chagas’ disease, affecting most of Central and South America, constituting a significant health and socio-economic problem. The parasite has a metabolism largely based on the consumption of amino acids, which participate in a diversity of metabolic pathways, leading to many crucial compounds for the survival of this parasite. Study of its enzymes has the potential to disclose new therapeutic targets and foster the development of new drugs.

General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis

F. B. M. Arraes, Benoliel, B., Burtet, R. T., Costa, P. L. N., Galdino, A. S., Lima, L. H. A., Marinho-Silva, C., Oliveira-Pereira, L., Pfrimer, P., Procópio-Silva, L., Reis, V. Castelo- Br, and Felipe, M. Sueli S., “General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis”, vol. 4, pp. 290-308, 2005.

Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehalose; these provide energy reserves that are relevant for metabolic adaptation, protection against stress and infectivity mechanisms. The glyoxylate cycle, which is also involved in pathogenicity, is present in this fungus.

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