Metabolic syndrome

Relationship between polymorphism of SOCS-3 and dyslipidemia in China Xinjiang Uygur

X. G. Yao, Meng, J., Zhou, L., Lin, N., Hong, J., Heizhati, M., and Li, N. F., Relationship between polymorphism of SOCS-3 and dyslipidemia in China Xinjiang Uygur, vol. 14, pp. 1338-1346, 2015.

We investigated the relationship between the polymorphism of SOCS-3 and dyslipidemia of people from Uygur in Xinjiang, China. This cross-sectional study included 1379 participants in a Hetian Xinjiang Uygur population who were 30-70 years of age and were not from interracial marriages of 3 generations; all subjects were genotyped (909 dyslipidemia subjects, 470 healthy subjects). Allele (P = 0.002) and genotype (P = 0.003) frequencies of the distribution of rs12953258 was significantly different between dyslipidemia and control groups.

Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

Y. Liu, Wu, G., Han, L., Zhao, K., Qu, Y., Xu, A., and Huang, Q., Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis, vol. 14, pp. 1155-1168, 2015.

Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and metabolic syndrome (315 cases, 323 controls) by logistic regression analysis in a Chinese study cohort recruited from Yichang, Hubei Province.

Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes

Y. L. Chen, Pei, D., Hung, Y. J., Lee, C. H., Hsiao, F. C., Wu, C. Z., Lin, J. D., Hsu, C. H., Chang, J. B., and Hsieh, C. H., Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes, vol. 14, pp. 2518-2526, 2015.

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects aged 35-64 years were recruited. Waist circumstance, plasma triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, and blood pressure were measured to define MetS.

Polymorphisms in the PPARγ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China

J. Chen, Ma, R. L., Guo, H., Ding, Y. S., Zhang, J. Y., Liu, J. M., Kerm, M., Zhang, M., Xu, S. Z., Li, S. G., and Guo, S. X., Polymorphisms in the PPARγ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China, vol. 14, pp. 6279-6288, 2015.

We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARγ gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. Mass spectrometry techniques were used to detect the PPARγ genotypes rs1801282 and rs3856806 in 987 subjects, CC genotype and C allele frequencies were 83.6 and 91.7%, respectively, at rs1801282 in Kazakhs, which were higher than those in Uyghurs (72.3 and 85.0%, respectively; P

Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population

H. M. Wang, Li, N. F., Hong, J., Zhou, L., and Chang, J. H., Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population, vol. 13, pp. 22-31, 2014.

Genetic variation is thought to contribute to etiology of metabolic syndrome (MS). Neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) is a candidate gene for MS. This study investigated the relationship between variations of NEDD4L and MS in the Kazakh, which is an ideal population to study the genetic mechanisms of complex diseases such as MS. We screened the promoter and exons of NEDD4L in 48 Kazakh individuals with MS to identify representative variations.

Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents

Y. Wei, Liu, G. L., Yang, J. Y., Zheng, R. X., Jiang, L. H., Li, Y. P., and Gao, F. F., Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents, vol. 13, pp. 8671-8678, 2014.

We aimed at investigating the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in children and adolescents. Sixty children (30 obese children and 30 children with MS) were included in this retrospective analysis. Thirty healthy subjects were randomly selected as the control group. A series of indices/biomarkers known to be related to MS/ECD were determined using ELISA. Correlations between the variables measured were analyzed. Compared with the control group, PAI-1, vWF, VE-cad, TM, and VEGF were significantly increased in the MS group (P

Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province

S. X. Guo, Guo, H., Ma, R. L., Ding, Y. S., Zhang, J. Y., Liu, J. M., Zhang, M., Niu, Q., Qiang, N., Li, S. G., and Qi, C. N., Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province, vol. 13, pp. 8686-8694, 2014.

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.

11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

F. Atalar, Vural, B., Ciftci, C., Demirkan, A., Akan, G., Susleyici-Duman, B., Gunay, D., Akpinar, B., Sagbas, E., Ozbek, U., and Buyukdevrim, A. S., 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease, vol. 11, pp. 3122-3132, 2012.

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the development of coronary atherosclerosis.

Plasma chemerin level in metabolic syndrome

D. Wang, Yuan, G. - Y., Wang, X. - Z., Jia, J., Di, L. - L., Yang, L., Chen, X., Qian, F. - F., and Chen, J. - J., Plasma chemerin level in metabolic syndrome, vol. 12, pp. 5986-5991, 2013.

To investigate the chemerin level in the Chinese Han population with metabolic syndrome and its relationship with each metabolic syndrome component [body mass index (BMI), blood pressure, blood lipids, and blood glucose], we selected 30 patients with metabolic syndrome and 30 healthy control subjects. The chemerin level was measured by enzyme immunoassay in these 2 groups. The subjects’ weight, blood pressure, BMI, waist circumference, fasting blood glucose, fasting insulin, lipids, and glycated hemoglobin were simultaneously detected.

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