Meta-analysis

Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk

G. Nie, Xie, C. L., Cao, Y. J., Xu, M. M., Shi, X., Zou, A. L., Qi, J. H., Nie, G., Xie, C. L., Cao, Y. J., Xu, M. M., Shi, X., Zou, A. L., and Qi, J. H., “Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk”, vol. 15, p. -, 2016.

Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubMed and Embase databases was conducted to identify all eligible studies published before October 29, 2015. Four case-control studies involving 651 psoriasis cases and 552 controls were included in this meta-analysis.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., Zhang, J. W., Liu, J. J., Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., “Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population”, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., “Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population”, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis

N. Wang, Chen, P., Huang, L. P., Wang, T. Z., Wang, N., Chen, P., Huang, L. P., Wang, T. Z., Wang, N., Chen, P., Huang, L. P., and Wang, T. Z., “Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis”, vol. 15, p. -, 2016.

Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang databases to identify studies on the prognostic role of miR-10b expression in breast cancer. A total of 770 patients from 7 eligible studies were included in the analysis.

Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis

S. Denden, Bouden, B., A. Khelil, H., Ben Chibani, J., Hamdaoui, M. H., Denden, S., Bouden, B., A. Khelil, H., Ben Chibani, J., Hamdaoui, M. H., Denden, S., Bouden, B., A. Khelil, H., Ben Chibani, J., and Hamdaoui, M. H., “Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis”, vol. 15, p. -, 2016.

The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the odds ratio (OR) of genotypes AA (conferring fast caffeine metabolism) vs AC + CC (conferring slow caffeine metabolism).

Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis

Y. Yang, Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., and Liu, H., “Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis”, vol. 15, p. -, 2016.

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science, and the China Knowledge Resource Integrated Database for papers on MTHFR gene C677T and A1298C polymorphisms and male infertility risk.

Association between RASSF1A promoter methylation and renal cell cancer susceptibility: a meta-analysis

Y. Q. Huang, Guan, H., Liu, C. H., Liu, D. C., Xu, B., Jiang, L., Lin, Z. X., Chen, M., Huang, Y. Q., Guan, H., Liu, C. H., Liu, D. C., Xu, B., Jiang, L., Lin, Z. X., Chen, M., Huang, Y. Q., Guan, H., Liu, C. H., Liu, D. C., Xu, B., Jiang, L., Lin, Z. X., and Chen, M., “Association between RASSF1A promoter methylation and renal cell cancer susceptibility: a meta-analysis”, vol. 15, p. -, 2016.

Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published studies reporting correlations between methylation frequency of the RASSF1A promoter region and renal cancer risk.

MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Y. Yang, Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., and Liu, H., “MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation”, vol. 15, p. -, 2016.

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource Integrated Database for papers on C677T and A1298C and susceptibility to lung cancer was performed. The STATA software (Version 13.0) was used for statistical analysis.

135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis

L. Wu, Long, Z. G., Dai, Z. S., Wu, L., Long, Z. G., Dai, Z. S., Wu, L., Long, Z. G., and Dai, Z. S., “135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis”, vol. 15, p. -, 2016.

Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis. PubMed, Google Scholar, and Web of Science databases were systematically searched to identify relevant studies from their inception to June 2015.

Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining

L. An, Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., and Hua, L., “Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining”, vol. 15, p. -, 2016.

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. In recent years, as one of the most widely studied genes including tests for associations between a genetic variant and COPD, epoxide hydrolase 1 (EPHX1) was found to be involved in the metabolism of tobacco smoke, an important risk factor of COPD.

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