Meta-analysis

Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis

L. L. Shen, Gu, D. Y., Zhao, T. T., Tang, C. J., Xu, Y., and Chen, J. F., Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis, vol. 14, pp. 13735-13745, 2015.

A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors. However, the clinical outcomes were inconsistent. Therefore, this meta-analysis was conducted to summarize the effect of the H63D variant on the incidence of solid tumor. PubMed and EMBASE databases were searched for articles associating the HFE H63D polymorphism with cancer risk.

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