Meta-analysis

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

G. J. Zhou, Xiao, M., Zhao, L. N., Tang, J. G., and Zhang, L., MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis, vol. 14, pp. 7279-7289, 2015.

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis

H. B. Xu, Wang, H. D., Li, C. H., Ye, S., Dong, M. S., Xia, Q. J., Zhang, A. Q., Pan, K., Ge, X. L., and Dong, J. H., Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis, vol. 14, pp. 7490-7501, 2015.

We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The primary outcome was SBP, and the secondary outcome was overall bacterial infection. Results were pooled using random-effect models. This process led to identification of 12 journal articles and 5 conference abstracts.

Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies

Y. Zhao, Liang, J., Qi, J. G., Yang, N., Wu, G., Lin, Y. L., Cao, J. Y., Wang, Q., and Wang, Q. C., Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies, vol. 14, pp. 7426-7435, 2015.

Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through May 18, 2014, were conducted across several databases. Additional studies were identified manually, and only the most recent or complete were used in this meta-analysis.

Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis

D. B. Tian, Cai, S. X., Pan, G. C., Zhang, Y. F., and Xiao, J. H., Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis, vol. 14, pp. 7920-7928, 2015.

The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD.

Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Y. H. Lee and Song, G. G., Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis, vol. 14, pp. 8602-8612, 2015.

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility.

Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis

Y. P. Gu, Yuan, Q. Y., Zhang, H., Wang, C. J., and Zhou, F., Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis, vol. 14, pp. 8375-8387, 2015.

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the correlation between the miR-146a G>C, miR-196a-2 C>T, miR-499 T>C, miRNA-27a A>G, and miRNA-149 T>C polymorphisms and the susceptibility to GC.

Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis

J. A. Zhang, Li, J. R., and Qiao, Y. J., Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis, vol. 14, pp. 9163-9170, 2015.

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software.

Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis

Y. Zhang, Yu, Y. F., Wang, J. Z., and Jia, H., Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis, vol. 14, pp. 8909-8918, 2015.

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case-control studies were included in this meta-analysis.

Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis

J. Z. Peng, Xue, L., Liu, D. G., and Lin, Y. H., Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis, vol. 14, pp. 9024-9033, 2015.

Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients and 5115 controls were involved in this meta-analysis.

Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis

J. H. Qi, Qi, J., Xiang, L. N., and Nie, G., Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis, vol. 14, pp. 9595-9603, 2015.

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the association between IL-21 rs907715 and rs2221903 polymorphisms and SLE. Studies regarding these specific polymorphisms and SLE were retrieved from PubMed, Embase, Web of Science, CNKI, and CBM.

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