Effect of 1,25(OHD on the proliferation of human mesangial cells and their expression of Ki67.
“Effect of 1,25(OHD on the proliferation of human mesangial cells and their expression of Ki67.”, Genet Mol Res, vol. 16, no. 2, 2017.,
Recent studies have found that bradykinin (BK) plays a role in delaying glomerulosclerosis, although the mechanism of this phenomenon remains unclear. Mesangial cell proliferation (MCP) and extracellular matrix (ECM) secretion are important mechanisms for glomerulosclerosis. This study investigated the impact of BK on the platelet-derived growth factor (PDGF)-induced proliferation of mesangial cells, and evaluated its correlations with the extracellular signal-related kinase (ERK) signaling pathway.