meningiomas

Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation

P. Wang, Ni, R. Y., Chen, M. N., Mou, K. J., Mao, Q., and Liu, Y. H., Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation, vol. 10, pp. 2165-2171, 2011.

Peritumoral brain edema is a common complication of meningiomas. It is believed that vascular endothelial growth factor (VEGF), as an angiogenic factor, plays a vital role in edema formation. Aquaporin-4 (AQP4) is a small integral membrane protein that regulates water in the normal brain. However, the expression of AQP4 and its relationship to VEGF in edematous meningiomas are not well known. We studied tumor specimens of 59 human supratentorial meningiomas.

Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors

L. O. Almeida, Custódio, A. C., Pinto, G. R., Santos, M. J., Almeida, J. R. W., Clara, C. A., Rey, J. A., and Casartelli, C., Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors, vol. 8, pp. 8-18, 2009.

The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determined susceptibility in various types of cancer. Another process involved with the development and progression of tumors is DNA hypermethylation.

Subscribe to meningiomas