Mechanism

Induction of apoptosis in human cervical carcinoma Hela cells with active components of Menispermum dauricum

J. Y. Wang, Sun, S., Liu, L., and Yang, W. S., Induction of apoptosis in human cervical carcinoma Hela cells with active components of Menispermum dauricum, vol. 13, pp. 3545-3552, 2014.

Menispermum dauricum DC possesses a wide range of pharmacological effects. In this study, the mechanism of apoptosis induced by active components of M. dauricum was investigated in the human cervical carcinoma HeLa cell line. HeLa cells were treated with different M. dauricum concentrations over different time periods. The proliferation-inhibitory rate and cytotoxic effect of HeLa cells were measured by using the methyl thiazolyl tetrazolium (MTT) assay, and the apoptotic rate was detected by flow cytometry.

HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes

Y. L. Hu, Zhong, D., Pang, F., Ning, Q. Y., Zhang, Y. Y., Li, G., Wu, J. Z., and Mo, Z. N., HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes, vol. 12, pp. 1327-1335, 2013.

Prostate cancer is one of the most commonly diagnosed male malignancies. Genome wide association studies have revealed HNF1b to be a major risk gene for prostate cancer susceptibility. We examined the mechanisms of involvement of HNF1b in prostate cancer development. We integrated data from Gene Expression Omnibus prostate cancer genes from the Dragon Database of Genes Implicated in Prostate Cancer, and used meta-analysis data to generate a panel of HNF1b-associated prostate cancer risk genes.

Understanding bamboo flowering based on large-scale analysis of expressed sequence tags

X. C. Lin, Chow, T. Y., Chen, H. H., Liu, C. C., Chou, S. J., Huang, B. L., Kuo, C. I., Wen, C. K., Huang, L. C., and Fang, W., Understanding bamboo flowering based on large-scale analysis of expressed sequence tags, vol. 9, pp. 1085-1093, 2010.

Unlike other plants, bamboo (Bambusoideae) flowering is an elusive physiological phenomena, because it is unpredictable, long-periodic, gregarious, and uncontrollable; also, bamboo plants usually die after flowering. The flowering mechanism in Arabidopsis thaliana, a eudicot model species, is well established, but it remains unknown in bamboo species. We found 4470 and 3878 expressed sequence tags in the flower bud and vegetative shoot cDNA libraries, respectively, of the bamboo species, Bambusa oldhamii.

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