Meat quality traits

Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens)

M. Chu, Wu, X. Y., Guo, X., Pei, J., Jiao, F., Fang, H. T., Liang, C. N., Ding, X. Z., Bao, P. J., and Yan, P., Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens), vol. 14, pp. 2617-2625, 2015.

Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing techniques. SNP g.5477C>T is located in intron 3 of FASN, and 3 genotypes, HH, HG, and GG, were detected in this mutation site.

Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle

C. Z. Fu, Tian, W. Q., Li, Y. K., Wei, S. J., Cheng, G., Wang, H. B., and Zan, L. S., Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle, vol. 14, pp. 3669-3679, 2015.

Body measurement and meat quality traits play important roles in the evaluation of productivity and economy in cattle, which are influenced by genes and environmental factors. PRKAG2, which encodes the γ2 regulatory subunit of AMPK, is associated with key metabolic pathways in muscle. We detected bovine PRKAG2 gene polymorphisms and analyzed their associations with body measurement and meat quality traits of cattle. DNA samples were taken from 578 Qinchuan cattle aged 18-24 months.

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle

Y. F. Huangfu, Zan, L. S., Adoligbe, C., Wang, H. B., Wang, H., and Gao, J. B., Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle, vol. 14, pp. 4890-4895, 2015.

Here, we detected 2 SNPs, A85C and T335C, that were located on the 3rd exon and the 3 untranslated regions of the bovine Osteocrin gene, respectively, using 413 Qinchuan cattle DNA samples. PCR-SSCP and DNA sequencing methods were specifically used. Three genotypes (AA, AC, and CC) were found at A85C; yet, only 2 genotypes (TC and CC) were found at T335C. Association analysis showed that both loci were associated with certain meat quality traits, including back fat thickness and loin muscle area. At the A85C locus, individuals with the CC genotype had greater back fat thickness.

Rabbit MSTN gene polymorphisms and genetic effect analysis

X. B. Qiao, Xu, K. Y., Li, B., Luan, X., Xia, T., and Fan, X. Z., Rabbit MSTN gene polymorphisms and genetic effect analysis, vol. 13, pp. 2590-2597, 2014.

We analyzed meat samples of nine pure lines of rabbit and its 37 hybrid combinations by sequencing and single-strand conformation polymorphism techniques to explore genetic polymorphisms of all the three exon regions and part of the 5'-regulatory region of the myostatin (MSTN) gene. Thus, we detected a single nucleotide mutation (T→C) on the 476 locus of the 5'-regulatory region, but no mutation sites were detected in the exon areas.

New polymorphisms in the novel LYRM1 gene are associated with body measurement and meat quality traits in Qinchuan cattle

Y. K. Li, Huangpu, Y. F., Gao, J. B., Yang, N., Fu, C. Z., Wang, H. B., Cheng, G., and Zan, L. S., New polymorphisms in the novel LYRM1 gene are associated with body measurement and meat quality traits in Qinchuan cattle, vol. 13, pp. 6926-6936, 2014.

Body measurement and meat quality traits play important roles in the evaluation of productivity in cattle; they are influenced by genetic and environmental factors. Recent studies have shown that LYRM1 is a novel gene related to obesity and may influence fat deposition. We screened for new polymorphisms in the bovine LYRM1 gene and analyzed their association with body measurement and meat quality traits in cattle. DNA samples were obtained from 572 Qinchuan cattle aged from 18 to 24 months. DNA sequencing was used to find the LYRM1 single nucleotide polymorphisms (SNPs).

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Y. R. Zhang, Li, Y. K., Fu, C. Z., Wang, J. L., Wang, H. B., and Zan, L. S., Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle, vol. 13, pp. 8105-8117, 2014.

Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contributes to the regulation of both osteogenesis and adipogenesis through the hedgehog pathway.

A novel polymorphism of the MYPN gene and its association with meat quality traits in Bos taurus

Y. Jiao, Zan, L. S., Liu, Y. F., Wang, H. B., and Guo, B. L., A novel polymorphism of the MYPN gene and its association with meat quality traits in Bos taurus, vol. 9, pp. 1751-1758, 2010.

Myopalladin (MYPN) is a multifunctional protein that maintains sarcomeric integrity and regulates Z-line structure. It is an important candidate gene for meat quality selection through marker-assisted selection. Using PCR-RFLP technology, we discovered a single-nucleotide polymorphism (SNP) (A1795G in exon 9) of the MYPN gene. Allele frequencies of this SNP were investigated and evaluated by the χ2 test in 660 cattle populations in China; only the Nanyang population was not in Hardy-Weinberg equilibrium.

A novel SNP of the C/EBPα gene associated with superior meat quality in indigenous Chinese cattle

H. Wang, Zan, L. S., Wang, H. B., and Song, F. B., A novel SNP of the C/EBPα gene associated with superior meat quality in indigenous Chinese cattle, vol. 10, pp. 2069-2077, 2011.

CCAAT/enhancer-binding protein alpha (C/EBPa) is an essential transcriptional factor regulating the differentiation of adipocytes. We report a novel single nucleotide polymorphism (C271A) of the C/EBPa gene in six indigenous Chinese cattle breeds using PCR-SSCP and DNA sequencing methods. Allele frequencies were investigated and evaluated by the χ2 test in 817 individuals; all populations were found to be in Hardy-Weinberg equilibrium.

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