MDR1

1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients

S. A. Gutiérrez-Rubio, Quintero-Ramos, A., Durán-Cárdenas, A., Franco-Topete, R. A., Castro-Cervantes, J. M., Oceguera-Villanueva, A., Jiménez-Pérez, L. M., Balderas-Peña, L. M. A., Morgan-Villela, G., Del-Toro-Arreola, A., and Daneri-Navarro, A., “1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients”, vol. 14, pp. 1250-1259, 2015.

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification.

MDR1 C3435T polymorphism in Mexican patients with breast cancer

N. M. Macías-Gómez, Gutierrez-Angulo, M., Leal-Ugarte, E., Ramírez-Reyes, L., Peregrina-Sandoval, J., Meza-Espinoza, J. P., F. Solano, R., M. Ayala-Madrigal, dela Luz, and F. Telles, S., “MDR1 C3435T polymorphism in Mexican patients with breast cancer”, vol. 13, pp. 5018-5024, 2014.

We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (México) were included in the analysis.

Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant

O. F. Khabour, Alzoubi, K. H., Al-Azzam, S. I., and Mhaidat, N. M., “Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant”, vol. 12, pp. 801-808, 2013.

The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an important role in regulating absorption, distribution, and elimination of drugs. We examined MDR1 gene variants in 100 unrelated subjects from various regions of Jordan. The MDR1 gene was scanned using direct sequencing. Six rare variants in MDR1 were detected, including a new variant, T3075A. This variant did not affect the protein sequence (synonym for threonine).

Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene

J. - S. Huang, Zhao, M. - D., Shi, J. - M., Zhang, J. - H., Li, B., Fan, W., and Zhou, Y. - L., “Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene”, vol. 12, pp. 5842-5850, 2013.

ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also a significant decrease in MDR1 and MRP1 gene expression. A significant reduction in expression of P-gp was found; however, there was no significant decrease in the expression of MRP1 and NF-κB p65.

Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever

A. Rüstemoglu, Gümüş-Akay, G., Yigit, S., and Tasliyurt, T., “Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever”, vol. 10, pp. 3411-3420, 2011.

The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a single gene named the Mediterranean fever gene (MEFV).

Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population

G. Gümüş-Akay, üstemoğlu, A. R., Karadağ, A., Sunguroĝlu, A., and Sunguroĝlu, A., “Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population”, vol. 7, pp. 1193-1199, 2008.

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to be of functional relevance and can also alter the pharmacokinetics of substrate drugs.

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles

T. Nakamura, Okamura, N., Yagi, M., Omatsu, H., Yamamori, M., Kuwahara, A., Nishiguchi, K., Horinouchi, M., Okumura, K., and Sakaeda, T., “Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles”, vol. 8, pp. 397-403, 2009.

ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the onset of menstruation, N = 22; menstrual phase, N = 11, and postmenstrual phase, N = 18). ABCB1 -129T>C, 1236C>T, 2677G>A/T, and 3435C>T genotypes were determined.