MCP-1

Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

L. Yang, Shi, G. L., Song, C. X., and Xu, S. F., Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China, vol. 9, pp. 765-771, 2010.

Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrelated healthy controls of Han nationality in North China using PCR-RFLP. We found that the distributions of AA, AG and GG genotypes of MCP-1-2518 were significantly different in NSCLC patients compared to controls (X2 = 10.106, P = 0.006).

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