Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose
“Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose”, vol. 14, pp. 3149-3159, 2015.
, We investigated the effect of p38MAPK/AP-1 (activator protein-1) signaling on the apoptosis of osteoblasts induced by high glucose. A lentivirus vector of small hairpin RNA (shRNA) targeting p38MAPK was constructed in vitro. Osteoblasts MC3T3-E1 cultured in vitro were treated with vehicle, high glucose, p38MAPK-shRNA transfection, p38MAPK inhibitor, and unrelated shRNA transfection.