MC3T3-E1 osteoblast

Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose

Z. P. Feng, Deng, H. C., Jiang, R., Du, J., and Cheng, D. Y., Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose, vol. 14, pp. 3149-3159, 2015.

We investigated the effect of p38MAPK/AP-1 (activator protein-1) signaling on the apoptosis of osteoblasts induced by high glucose. A lentivirus vector of small hairpin RNA (shRNA) targeting p38MAPK was constructed in vitro. Osteoblasts MC3T3-E1 cultured in vitro were treated with vehicle, high glucose, p38MAPK-shRNA transfection, p38MAPK inhibitor, and unrelated shRNA transfection.

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