Matrix metalloproteinases

Associations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarction

J. H. Zhao, Xu, Y. M., Xing, H. X., Su, L. L., Tao, S. B., Tian, X. J., Yan, H. Q., and Ji, S. B., Associations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarction, vol. 14, pp. 19418-19424, 2016.

The aim of this study was to investigate the association between MMP3 rs3025058 and MMP9 rs3918242 polymorphisms and the development of ischemic stroke in a Chinese population. Between May 2013 and January 2015, 335 patients with ischemic stroke and 335 health control subjects were enrolled in this study. The MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism.

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer

L. Zhang, Xi, R. - X., and Zhang, X. - Z., Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer, vol. 14, pp. 4616-4624, 2015.

We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy controls were enrolled in this study.

Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population

H. Schirmer, L. da Silva, B., Teixeira, P. J. Z., Moreira, J. S., Moreira, A. L. S., and Simon, D., Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population, vol. 8, pp. 1028-1034, 2009.

There are many candidate genes for chronic obstructive pulmonary disease (COPD). One such candidate is the group of genes that code for matrix metalloproteinases (MMPs), which play an essential role in tissue remodeling and repair associated with COPD. We tested the hypothesis that polymorphic variation in MMP genes influences the risk of developing COPD by examining functional polymorphisms in the promoters of MMP-3, MMP-9 and MMP-12 genes in 111 COPD patients and 101 controls.

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