Major histocompatibility complex

Analysis of DRB3 gene polymorphisms in Jafarabadi, Mediterranean, and Murrah buffaloes from Brazil

N. B. Stafuzza, Olivatto, L. M., Naressi, B. C. M., Tonhati, H., Amaral-Trusty, M. E. J., Stafuzza, N. B., Olivatto, L. M., Naressi, B. C. M., Tonhati, H., Amaral-Trusty, M. E. J., Stafuzza, N. B., Olivatto, L. M., Naressi, B. C. M., Tonhati, H., and Amaral-Trusty, M. E. J., “Analysis of DRB3 gene polymorphisms in Jafarabadi, Mediterranean, and Murrah buffaloes from Brazil”, vol. 15, p. -, 2016.

The DRB3 gene is an MHC class II gene that has a high degree of polymorphism with more than 100 alleles described in cattle. This variation contributes to differences among individuals in immune responsiveness and disease resistance. In this study, we searched for allelic variants in exon 2 of the DRB3 gene in 80 river buffaloes of three breeds in Brazil using a PCR-RFLP technique. The PCR product showed genetic polymorphism when digested with RsaI, PstI or HaeIII restriction enzymes.

Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China

L. P. Chen, E, G. X., Zhao, Y. J., Na, R. S., Zhao, Z. Q., Zhang, J. H., Ma, Y. H., Sun, Y. W., Zhong, T., Zhang, H. P., and Huang, Y. F., “Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China”, vol. 14. pp. 6925-6928, 2015.

DRA encodes the alpha chain of the DR heterodimer, is closely linked to DRB and is considered almost monomorphic in major histocompatibility complex region. In this study, we identified the exon 2 of DRA to evaluate the immunogenetic diversity of Chinese south indigenous goat. Two single nucleotide polymorphisms in an untranslated region and one synonymous substitution in coding region were identified. These data suggest that high immunodiversity in native Chinese population.

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