Lymph node

DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity

M. Santos, Maia, L. L., Silva, C. V. M., Peterle, G. T., Mercante, A. M. C., Nunes, F. D., Carvalho, M. B., Tajara, E. H., Louro, I. D., and Silva-Conforti, A. M. A., DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity, vol. 14, pp. 10515-10523, 2015.

Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cancer, and with prognosis and survival of diverse tumor types. Therefore, in this study we analyzed DAP1 expression in 54 oral squamous cell carcinoma tumor samples and in 20 non-tumoral margins by immunohistochemistry.

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