Lupus nephritis

Relationship between urinary protein changes in lupus nephritis and renal pathology

M. Li, Gao, W. J., Ma, J. J., Zhu, Y., and Li, X. F., Relationship between urinary protein changes in lupus nephritis and renal pathology, vol. 14, pp. 8352-8358, 2015.

This study investigated the relationship between urinary protein excretion in lupus nephritis New Zealand black mice and renal pathology. A total of 328 lupus nephritis New Zealand black mice were established by a backcross hybridization method, and renal pathology was determined. The urinary protein excretion of the backcross mice over 24 h was compared and analyzed. Urinary protein excretion over 24 h differed significantly across different pathological types (1.9, 2.4, 2.9 and 4.9 g in types II, III, IV, and V, respectively) in the backcross mice (P < 0.05).

Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis

X. F. Ma, Xu, F. L., Gao, L. F., Wang, Y. X., and Pan, Z. B., Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis, vol. 14, pp. 10999-11005, 2015.

We investigated the effect of age on the expression of immune molecules [ANA, C4, double stranded DNA (dsDNA), CD16/32, CD19, CD3, and CD64], urine protein, and pathology in mice with chronic graft-versus-host disease (cGVHD) lupus nephritis (LN), and their relationship with reactivity index score. Mouse models of cGVHD LN were established, and mice were randomly divided into four aged-based groups of nine mice each. Serum levels of ANA, C4, and dsDNA were determined, the urine protein levels were assessed, and expression levels of CD16/32, CD19, CD3, and CD64 were measured.

Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study

Z. Xie, Zhang, M., Zhao, B., Wang, Q., Li, J., Liu, Y. Y., and Chen, Y. H., Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study, vol. 13, pp. 9213-9219, 2014.

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined, and the association between AOPP levels and LN was investigated in a case-control study.

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