Lung cancer

Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer

X. P. Huang, Zhou, W. H., and Zhang, Y. F., Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer, vol. 13, pp. 2107-2119, 2014.

Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 15th, 2013. This meta-analysis was performed using the STATA 12.0 software.

Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine

M. Zhou, Ding, Y. J., Feng, Y., Zhang, Q. R., Xiang, Y., and Wan, H. Y., Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine, vol. 13, pp. 3310-3318, 2014.

Xeroderma pigmentosum group D (XPD) plays a key role in the repair of DNA and platinum resistance lesions. Cytidine deaminase (CDA) genes determine the velocity of gemcitabine catalysis. This study aimed to investigate the relationship between XPD and CDA genotypes and outcome in non-small lung cancer (NSCLC) patients. We used polymerase chain reaction-restriction fragment length polymorphism to evaluate genetic polymorphisms of XPD (Asp312Asn and Lys751Gln) and CDA (Lys27Gln and Ala70Thr) in 93 NSCLC patients treated with a cisplatin-gemcitabine regimen.

Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis

L. Li, Wan, C., and Wen, F. Q., Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis, vol. 13, pp. 3772-3786, 2014.

X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association between polymorphisms in the XRCC1 gene and response rate of platinum chemotherapy in advanced NSCLC patients.

Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer

X. Tan, Wang, Y. Y., Chen, X. Y., Xian, L., Guo, J. J., Liang, G. B., and Chen, M. W., Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer, vol. 13, pp. 7437-7446, 2014.

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was performed using the Pubmed and Embase databases. Odds ratios with 95% confidence intervals were used to assess the strength of associations.

XRCC3 T241M polymorphism and lung cancer risk in the Han Chinese population: a meta-analysis

J. H. Zhang, Wen, Q. L., Yang, C., Li, A. L., Liu, Y., and Li, X. S., XRCC3 T241M polymorphism and lung cancer risk in the Han Chinese population: a meta-analysis, vol. 13, pp. 9505-9513, 2014.

Numerous studies have evaluated the association between the X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphism and lung cancer risk; however, the actual association is controversial. We examined whether the T241M polymorphism confers a lung cancer risk in China. We searched the PubMed, Google Scholar, and China National Knowledge Infrastructure databases to identify studies that examined the association between the XRCC3 T241M polymorphism and the risk of lung cancer.

Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk

B. B. Sun, Wu, J. Z., Li, Y. G., and Ma, L. J., Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk, vol. 13, pp. 10223-10230, 2014.

Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a comprehensive meta-analysis in order to assess this association. Two independent reviewers extracted data from the studies, and ORs with 95%CIs were calculated.

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

X. F. Chen, Cai, S., Chen, Q. G., Ni, Z. H., Tang, J. H., Xu, D. W., and Wang, X. B., Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma, vol. 11, pp. 370-378, 2012.

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with lung cancer and 229 healthy individuals. TERT rs2736100 and CLPTM1L rs401681 and rs402710 were genotyped using the ABI TaqMan Allelic Discrimination assay.

The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population

H. Wang, Zhao, Y., Ma, J., Zhang, G., Mu, Y., Qi, G., Fang, Z., Wang, L., Fan, Q., and Ma, Z., The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population, vol. 12. pp. 67-73, 2013.

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, that is, rs401681 at 5p15.33 and rs8034191 at 15q25, in a case-control study with 492 LC cases and 486 cancer-free controls in a Chinese population.

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Z. Y. Zhang, Xuan, Y., Jin, X. Y., Tian, X., and Wu, R., A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer, vol. 12, pp. 3057-3069, 2013.

The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized the available evidence associating lung cancer with the CASP gene family.

Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts

P. K. Mishra, Bhargava, A., Raghuram, G. V., Gupta, S., Tiwari, S., Upadhyaya, R., Jain, S. K., and Maudar, K. K., Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts, vol. 8, pp. 129-143, 2009.

Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as inflammation and DNA damage and end with the development of cancer.

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