Meta-analysis of the relationship between p21 Ser31Arg polymorphism and lung cancer susceptibility
, “Meta-analysis of the relationship between p21 Ser31Arg polymorphism and lung cancer susceptibility”, vol. 10, pp. 2449-2456, 2011.
The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stratified meta-analysis based on ethnicity, lung cancer subtypes and source of controls, with six eligible studies (2366 cases and 3320 controls).
