Lung cancer

Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis

Y. W. Pan, Zhou, Z. G., Wang, M., Dong, J. Q., Du, K. P., Li, S., Liu, Y. L., Lv, P. J., Gao, J. B., Pan, Y. W., Zhou, Z. G., Wang, M., Dong, J. Q., Du, K. P., Li, S., Liu, Y. L., Lv, P. J., and Gao, J. B., “Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

H. X. Liu, Li, J., Ye, B. G., Liu, H. X., Li, J., and Ye, B. G., “Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Y. Yang, Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., and Liu, H., “MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation”, vol. 15, p. -, 2016.

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource Integrated Database for papers on C677T and A1298C and susceptibility to lung cancer was performed. The STATA software (Version 13.0) was used for statistical analysis.

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells

S. F. Chen, Zhang, Z. Y., and Zhang, J. L., “Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells”, vol. 14, pp. 14548-14560, 2015.

It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATP‑binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in the overcoming of multidrug resistance are unclear.

XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people

X. Wang, Ma, K. W., Zhao, Y. G., Wang, G. J., and Li, W., “XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people”, vol. 14, pp. 15530-15538, 2015.

Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nu­cleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung cancer susceptibility and BER SNPs coupled with a wide range of epidemiological factors in a Chinese population.

AGER genetic polymorphisms increase risks of breast and lung cancers

N. C. Yin, Lang, X. P., Wang, X. D., and Liu, W., “AGER genetic polymorphisms increase risks of breast and lung cancers”, vol. 14, pp. 17776-17787, 2015.

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases.

Detecting circulating tumor cells in patients with advanced non-small cell lung cancer

Y. H. Xu, Zhou, J., and Pan, X. F., “Detecting circulating tumor cells in patients with advanced non-small cell lung cancer”, vol. 14, pp. 10352-10358, 2015.

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control group. Peripheral blood CTCs in the observation and control groups were detected using the CellSearch®.

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