Lung cancer

Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis

Y. Liu, Song, X. L., Zhang, G. L., Peng, A. M., Fu, P. F., Li, P., Tan, M., Li, X., Li, M., and Wang, C. H., Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis, vol. 14, pp. 163-169, 2015.

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized the Q-test and I2 test to determine heterogeneity between each study.

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

H. Liu, Ma, H. F., and Chen, Y. K., Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis, vol. 14, pp. 1385-1392, 2015.

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a random-effect model to pool the odds ratios (ORs) and 95% confidence intervals (CIs).

Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells

J. Z. Mei, Liu, G. J., Zhang, X. J., Zhao, J. Z., and Feng, R. T., Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells, vol. 14, pp. 3082-3089, 2015.

We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and EGFR downstream molecules, including LY294002 (phosphoinositide 3-kinase inhibitor), SB203580 (mitogen-activated protein kinase inhibitor), and STAT21 (signal transduction and transcription 3 inhibitor) after 24 h.

Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299

G. M. Chen, Ding, R. F., Tan, Y. D., Pan, X. B., Jiang, G. M., He, J. F., Lin, S. H., Liu, C., and Jia, Y., Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299, vol. 14, pp. 4005-4014, 2015.

Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies examining the function of CKIP1 in cancer cells have been performed. The present study aimed to investigate the role of CKIP1 in lung cancer.

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population

S. G. Liu, Ma, L., Cen, Q. H., Huang, J. S., Zhang, J. X., and Zhang, J. J., Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population, vol. 14, pp. 4469-4476, 2015.

Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased risk of lung cancer in the Chinese Han population is unknown.

Computed tomography-guided percutaneous microwave ablation therapy for lung cancer

Y. H. Sun, Song, P. Y., Guo, Y., and Sheng, L. J., Computed tomography-guided percutaneous microwave ablation therapy for lung cancer, vol. 14, pp. 4858-4864, 2015.

This study evaluated the clinical efficacy and value of computed tomography (CT)-guided percutaneous microwave ablation therapy (PMAT) for lung cancer without surgical treatment. A total of 39 lesions in 29 patients with peripheral lung cancer were treated by CT-guided PMAT under local anesthesia. The microwave energy was 50-70 W at a frequency of 2450 MHz. The treatment was performed by using 1 or 2 points of ablation emission according to the size and shape of the tumor. Operations were completed in 29 patients. The average operating time was 8 min (range: 5-12 min).

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

L. Q. Shen, Xie, Y. Z., Qian, X. F., Zhuang, Z. X., Jiao, Y., and Qi, X. F., A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese, vol. 14, pp. 4505-4512, 2015.

Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we examined whether a single-nucleotide polymorphism in the promoter region of the let-7 family (rs10877887) is associated with the susceptibility to and prognosis of lung adenocarcinoma cancer.

Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China

Y. Fang, Yang, H. Y., Shi, Y. H., Cui, J. H., Li, L. Y., Xu, Y. C., and Shao, J. L., Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China, vol. 14, pp. 5031-5043, 2015.

Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactors in the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-cancerous normal and distant normal tissues for 79 Chinese patients with lung cancer were analyzed in this study.

Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model

Q. - F. Gui, Lu, H. - F., Zhang, C. - X., Xu, Z. - R., and Yang, Y. - H., Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model, vol. 14, pp. 5642-5651, 2015.

The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the antitumor roles of the intestinal microbiota using the Lewis lung cancer mouse model.

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

X. L. Zhang, Zhang, X. J., Chen, Y., Zhang, Y. M., Zhang, Q., Cao, C. X., Gu, D. Y., Shi, J. F., Gong, Y. L., Chen, J. F., and Tang, C. J., Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis, vol. 13, pp. 1373-1382, 2014.

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we performed a meta-analysis of eight eligible studies involving 9935 cases and 11,261 controls.

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