Lung adenocarcinoma

Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples

Y. Guan, Wang, Z. J., Wang, L. Q., Hua, D. F., Liu, J., Guan, Y., Wang, Z. J., Wang, L. Q., Hua, D. F., Liu, J., Guan, Y., Wang, Z. J., Wang, L. Q., Hua, D. F., and Liu, J., Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples, vol. 15, p. -, 2016.

The goal of the current study was to investigate the differences in epidermal growth factor receptor (EGFR) mutation rates in tumor tissue and pleural effusion specimens from patients with lung adenocarcinoma. PCR amplification and gene sequencing were used to detect EGFR mutations in exons 18, 19, 20, and 21 in tumor tissue and pleural effusion samples from 50 patients with advanced lung adenocarcinoma. The EGFR mutation rate was 34.0% in tissue samples from patients with advanced lung adenocarcinoma. There were 11 cases with exon 19 mutations and 6 cases with exon 21 mutations.

Effects of kinase insert domain receptor (KDR) gene silencing on the sensitivity of A549 cells to erlotinib

W. L. Zhu and Liu, Y. H., Effects of kinase insert domain receptor (KDR) gene silencing on the sensitivity of A549 cells to erlotinib, vol. 14, pp. 15073-15080, 2015.

We investigated the effects of kinase insert domain receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to erlotinib. A KDR small interfering RNA (siRNA) sequence was designed and synthesized; then, it was transfected into A549 cells using LipofectamineTM 2000. KDR mRNA and protein expression after KDR gene silencing was detected by reverse transcription polymerase chain reaction and western blotting; the A549 cell cycle was detected by flow cytometry.

Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance

X. Yu, Li, Y., Chen, S. W., Shi, Y., and Xu, F., Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance, vol. 14, pp. 10185-10192, 2015.

In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients with lung squamous cell carcinoma or lung adenocarcinoma.

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